Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

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This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota Bottom Bracket and interleukin-17 (IL-17) expression.Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e.lowering the ratio of Firmicutes: Bacteroidetes).

In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight.Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway.In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum.Activation of mTOR signalling in mouse increased expression of IL-17 in the jejunum in the context of chitosan supplementation.

We conclude that chitosan supplementation reduces mouse body weight through the intestinal microbiota, and inhibits intestinal IL-17 expression through the Mirrored Dresser with Fireplace mTOR signalling.The discovery of this study suggests the potentials of chitosan as a functional supplement in intestinal health.